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KMID : 0369819910210020091
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 2 p.91 ~ p.95
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Drug Release Characteristics of Crosslinked Poly ( alkylene oxide ) Hydrogels
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김신정/Kim SJ
이승진/Lee SJ
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Abstract
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Polyethylene glycol, polypropylene glycol and block copolymer of ethylene glycol and propylene glycol were crosslinked by triisocyanate to form water swellable, rubbery polymer. The equilibrium swelling of the hydrogels ranged from 3% to 60% according to the hydrophobic-hydrophilic properties of the prepolymers. Model drugs, sodium salicylate and prednisolone were incorporated in the polymer matrices by swelling loading. Physical properties of the drugs affected the drug release mechanisms due to the change in the swelling behaviors of the polymeric devices. Zero order release was observed in the case of relatively hydrophobic polymer matrices.
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KEYWORD
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